BOOK Treatment


Experience a bio-stimulating revolution with Nucleofill, an injectable treatment packed with polynucleotides to deeply renew and rejuvenate your skin, revealing a visibly firmer, smoother, and more radiant complexion.

From £



Procedure Time

30 Mins - 60 Mins

Risks & Complications

Temporary redness, swelling, or bruising (uncommon)- Mild tenderness or itching at the injection sites (rare) - Allergic reactions (very rare)

Back To WorK


Recommended Treatment

2 Treatments recommended


Expect immediate hydration and a refreshed look. Full benefits develop over 4-6 weeks


6-12 months depending on your skin type and lifestyle




The treated area may be slightly pink initially, but this should subside quickly.

More About:


Cleansing & Preparation: The treatment area is cleansed and prepped for optimal product absorption.

Targeted Injection: Tiny amounts of Nucleofill are precisely injected into targeted areas on your face, neck, or hands.

Hydration Boost: The formula delivers immediate hydration and plumps up your skin.

Bio-Stimulation: Polynucleotides kickstart your skin's natural renewal process, promoting collagen and elastin production for long-term benefits.

Relaxation & Comfort: Enjoy a comfortable and minimally invasive experience with optional topical anaesthetic.

Risks & Complications:

Generally safe, potential side effects include:

  • Temporary redness, swelling, or bruising (uncommon)
  • Mild tenderness or itching at the injection sites (rare)
  • Allergic reactions (very rare)

How Does



Nucleofill utilizes polynucleotides, natural fragments of DNA and RNA present in your cells. These unique ingredients:

  • Hydrate your skin: They bind to water, attracting and retaining moisture for immediate plumping and smoothness.
  • Stimulate collagen & elastin: They activate fibroblasts, your skin's collagen and elastin producers, leading to firmer, more elastic skin over time.
  • Protect against free radicals: They act as antioxidants, shielding your skin from damage and promoting a youthful appearance.

What Can


Treat ?

What Can It Treat?

  • Fine lines and wrinkles
  • Loss of volume and sagging skin
  • Dehydration and dryness
  • Uneven skin tone and texture
  • Photoaging and sun damage

What Does


Treatment Involve ?

The procedure typically lasts 30-60 minutes, involving multiple tiny injections. Comfort measures like topical anesthetic can be used.


Unwind and revitalise in our historic and beautiful Castle spa.

Our therapist will listen to your needs and desires and tailor a massage to ensure you leave feeling refreshed, relaxed and rejuvenated.  

With a botanical blissful atmosphere, you will be welcomed with a drink of your choice, every detail will be cared for, you will feel your tension melt away.

All of our massages include luxurious extras which are certain to make them an experience unlike any others.

Our massages are enhanced with the timeless and ancient power of essential oils.

Your therapist will choose the oil specific to you, to intensify the results and your experience.

Feel free to be open and honest with our lovely therapist, to achieve the best outcome for you

You can book a massage alone, or indulge in one of our carefully planned and chosen rituals to make the most out of your visit.

Brows & Lashes

Our lash and eyebrow services are a great introduction to our clinic. A great excuse to come visit the Exeter Castle. Enjoy our range of treatments to fall back in love with your brows and lashes. We cater for all Genders!

All the treatments are performed by our expert spa therapist who has many years of spa and beauty therapist experience.


Whether you’re an experienced client, or new to the world of hair removal, we will take our time to give you quality treatment with excellent results.

Our therapist is professional, friendly and gentle.

With many years experience, working with clients from all backgrounds, all skin types and all nationalities our therapist will ensure you have a satisfying and enjoyable experience.

Luxury Manicure

Basque in the tranquility that is Aesthetica Medical Spa. You will leave feeling relaxed and as special as your are.

Not just a manicure. Sip your bubbly, lie back and relax whilst you enjoy world-renowned brand new luxury nail technology ‘Nails by Mii’ with outstanding service and results. A focus not just on aesthetic but on keeping your hands and nails healthy, supple and strong.

Before & After


Here are some frequently asked questions, cant find an answer? Get in touch and we will be happy to help!

Will Nucleofill injections hurt?

The injections are typically well-tolerated with minimal discomfort. Your doctor may use topical anesthetic for added comfort. Some people experience slight stinging or tenderness at the injection sites, but these effects usually subside quickly.

Are the results from Nucleofill permanent?

While the treated skin cells are renewed, Nucleofill's results aren't permanent. The effects typically last 6-12 months, depending on your skin type, lifestyle, and sun exposure. Maintaining a healthy lifestyle and considering maintenance treatments can help prolong the results and keep your skin looking its best.

How long does it take to see the full results from Nucleofill?

You'll notice immediate hydration and a refreshed appearance after the treatment. However, the full benefits, like firmer skin and reduced wrinkles, develop gradually over 4-6 weeks as your body naturally produces more collagen and elastin. Be patient and remember, individual results may vary.

More questions? Contact Us
Related Concerns Treated By: 


This treatment helps resolve the following concerns

Fine Lines & Wrinkles

Fine lines and wrinkles are natural signs of ageing, caused by a reduction in collagen and elastin production, leading to the loss of skin elasticity. These lines can appear on various areas of the face, including around the eyes, forehead, and mouth.

Tear Troughs

Upper Face
Tear Troughs, also known as under-eye hollows or dark circles, refer to the depressions or hollows that can form under the eyes, causing a tired or aged appearance. This condition is often influenced by factors such as genetics, ageing, and volume loss in the under-eye area.

Under Eye Bags / Tired Eyes

Upper Face
Under-eye bags or tired eyes are common concerns related to the appearance of puffiness, swelling, or dark circles beneath the eyes. These issues can result from factors such as ageing, genetics, lack of sleep, or lifestyle factors.


Mid Face
Cheeks enhancement refers to cosmetic procedures aimed at improving the appearance of the cheeks, addressing concerns such as volume loss, sagging, or asymmetry.

Mid Face Lift

Mid Face
A mid-face lift, also known as a cheek lift, is a cosmetic procedure designed to address sagging or drooping in the mid-face area.

Smile Lines (Nasolabial Folds)

Mid Face
Smile lines, also known as nasolabial folds, are the lines that extend from the sides of the nose to the corners of the mouth. These lines become more prominent with age, contributing to an aged or tired appearance.


Necklines refer to visible lines, wrinkles, and sagging skin on the neck area, often associated with aging, sun damage, and loss of skin elasticity. These signs can contribute to an aged appearance and impact overall aesthetic harmony.


Lower Face
Jowls refer to the sagging or drooping skin along the jawline, particularly on the lower part of the face

Skin Rejuvenation

Skin rejuvenation involves a range of advanced treatments aimed at revitalising and enhancing the skin's texture, tone, and overall appearance. This comprehensive approach addresses common concerns such as fine lines, wrinkles, uneven pigmentation, and loss of skin elasticity, promoting a more youthful and radiant complexion.
Related Treatments


These are other treatment options that you can consider

Dermal Filler

Dermal Fillers are non-surgical cosmetic enhancements that involve injecting gel-like substances beneath the skin to restore volume, smooth lines, and enhance facial contours.


Turn back time on dynamic wrinkles with anti-wrinkle injections, offering a minimally invasive option to soften expression lines and achieve a refreshed, youthful appearance.


Rejuvenate your skin from within with Sunekos, an innovative injectable treatment using a unique blend of hyaluronic acid and amino acids to bio-stimulate collagen and elastin production for a naturally smoother, plumper, and younger-looking complexion.

RF Microneedling

RF Microneedling is a cosmetic procedure that uses tiny needles and radiofrequency waves to rejuvenate facial skin. It involves controlled skin injury to stimulate collagen production.

HYDRO2 Facial

Escape to a haven of deep hydration and rejuvenation with the HydrO2 Facial. This multi-step treatment combines oxygen infusion, gentle exfoliation, and targeted serums for a radiant, plumped, and healthier complexion.

Obagi Blue Peel Radiance

The Obagi Blue Peel Radiance is a gentle, lunchtime peel that resurfaces and renews your skin, revealing a brighter, smoother, and more radiant complexion.

Online Booking

Use our fast online booking form to book this treatment or consultation

Here to help

Contact Aesthetica

For enquiries or to book an appointment, please reach out to us.

​Exeter Castle Castle Street, Exeter, EX43PU
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